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Major antiviral‐resistant viruses and key drugs used in clinical practice.

Journal: BioMed Research International

Article Title: Trends, Gaps, and Challenges in Antiviral Resistance: A Bibliometric Analysis and Narrative Synthesis of Key Viruses, Resistance Mechanisms, and Drivers

doi: 10.1155/bmri/3771603

Figure Lengend Snippet: Major antiviral‐resistant viruses and key drugs used in clinical practice.

Article Snippet: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) (Coronaviridae) , RNA‐dependent RNA polymerase (RdRp) inhibitors: remdesivir; oral RdRp‐targeting agent: molnupiravir; 3CL protease inhibitor: nirmatrelvir (in Paxlovid); monoclonal antibodies (e.g., earlier agents now largely inactive) , RdRp targeting: E802D, C799F, several others under selection; spike protein targeting (mAbs): many S domain mutations (e.g., E484K, N501Y related lineages that evade certain antibodies) , Potential for reduced drug susceptibility and escape from neutralizing antibodies; particular concern in immunocompromised hosts receiving prolonged therapy. , [ , ] .

Techniques: Virus, Reverse Transcription, Transmission Assay, Protease Inhibitor, Bioprocessing, Selection